The Kalamazoo station is one of five old train stations in Kalamazoo, Michigan. The first station was built on the site in 1870 by the Grand Rapids and Indiana Railroad. A fire damaged the building in 1874, and the current structure was built to replace it. Later, the station was used by the Pennsylvania Railroad and served as a stop for the Northern Arrow passenger train.

The building was named a Michigan State Historic Site on March 2, 1976.

The station is designed in the Italian Revival style.